|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In vitro experiments revealed that MANF suppressed the migration and invasion of hepatoma cells.
|
31469428 |
2019 |
|
Tumor Cell Invasion
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Total IgG levels to 11 different proteins known or predicted to be involved in reticulocyte binding or invasion (ARP, GAMA, P41, P12, PVX_081550, and five members of the PvRBP family), as well as the leading pre-erythrocytic vaccine candidate (CSP) were measured using a multiplexed bead-based assay.
|
28454546 |
2017 |
|
Syphilis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The sequence of the acidic repeat protein (arp) gene differentiates venereal from nonvenereal Treponema pallidum subspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis.
|
18554302 |
2008 |
|
Syphilis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
From September 2009 to August 2013, we collected 658 clinical specimens from 375 patients who presented with syphilis for genotyping to examine the number of 60-bp repeats in the acidic repeat protein (arp) gene, T. pallidum repeat (tpr) polymorphism, and tp0548 gene, and to detect A2058G and A2059G point mutations by restriction fragment length polymorphism.
|
24438059 |
2014 |
|
Subarachnoid Hemorrhage
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MANF was mainly expressed in rat neurons, and its expression increased significantly at 3 h after SAH induction and peaked at 24 h. Stereotactic injection of rh-MANF into the cerebroventricle significantly increased the level of MANF, p-Akt, p-mouse double minute 2 homolog (p-MDM2), and B-cell lymphoma 2 (Bcl-2) in brain tissue, whereas it down-regulated the expression of P53, Bcl-2-associated X protein (Bax), and cleaved caspase-3, which indicated that neuronal apoptosis was remarkably suppressed.
|
30211660 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, they were also found in its corresponding normal tissues, suggesting that variation of the ARP gene found in ESC is polymorphic.
|
10767373 |
2000 |
|
SPINOCEREBELLAR ATAXIA 17
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a recently identified neurotrophic factor, and increasing MANF expression ameliorated SCA17 neuropathology in TBP-105Q knock-in (KI) mouse model, indicating that MANF could be a therapeutic target for treating SCA17.
|
29378605 |
2018 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
As an endoplasmic reticulum (ER) stress-related protein, mesencephalic astrocyte-derived neurotrophic factor (MANF) is involved in inflammatory diseases, such as rheumatoid arthritis.
|
29649564 |
2018 |
|
Retinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Vitreous MANF may be a promising protein biomarker for the indirect assessment of retinal disorders, which could provide indirect evidence of retinal pathology.
|
28367115 |
2017 |
|
Retinal damage
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
It was recently shown that mesencephalic astrocyte-derived neurotrophic factor (MANF) induces alternative or M2 activation of immune cells after retinal damage in both fruit fly and mouse and mediates retinal repair.
|
29806020 |
2018 |
|
Reperfusion Injury
|
0.200 |
Biomarker
|
disease |
RGD |
Induction profile of MANF/ARMET by cerebral ischemia and its implication for neuron protection.
|
19773801 |
2010 |
|
Renal Cell Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We amplified and sequenced the multiple arginine coding area of the ARP gene in primary head and neck, non-small cell lung, and renal cell cancers.
|
9230196 |
1997 |
|
Renal Cell Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas.
|
8649854 |
1996 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Therefore, MANF may be a cancer suppressor and a potential therapeutic target for HCC.
|
31469428 |
2019 |
|
Prediabetes syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We concluded that serum MANF level was higher in patients with newly diagnosed prediabetes and T2DM than in NGT controls.
|
28216543 |
2017 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) promote the survival of midbrain dopaminergic neurons which degenerate in Parkinson's disease (PD).
|
27425895 |
2017 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, little is known about endogenous concentrations of MANF and CDNF in human PD patients, and their relation to PD pathogenesis.
|
31555085 |
2019 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects neurons and repairs the Parkinson disease-like symptoms in a rat 6-hydroxydopamine model.
|
21047780 |
2011 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In particular, studies employing glial cell line-derived neurotrophic factor (GDNF) and its family member neurturin (NRTN), as well as the recently described cerebral dopamine neurotrophic factor (CDNF) and the mesencephalic astrocyte-derived neurotrophic factor (MANF) have shown positive results in protecting and repairing dopaminergic neurons in various models of PD.
|
26616211 |
2016 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mesencephalic astrocyte-derived neurotrophic factor (MANF) was originally identified as a secreted trophic factor for dopamine neurons <i>in vitro.</i> It protects and restores damaged cells in rodent models of Parkinson's disease, brain and heart ischemia, spinocerebellar ataxia and retina <i>in vivo</i>.
|
30386256 |
2018 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Intrastriatal injection of mesencephalic astrocyte-derived neurotrophic factor (MANF) protein has been shown to provide neuroprotective and neurorestorative effects in a 6-hydroxydopamine (6-OHDA) - lesioned rat model of Parkinson's disease.
|
28131727 |
2017 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The selective, neuroprotective effect of MANF for dopaminergic neurons suggests that it may be indicated for the treatment of Parkinson's disease.
|
12794311 |
2003 |
|
Parkinson Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Enhanced efficacy of the CDNF/MANF family by combined intranigral overexpression in the 6-OHDA rat model of Parkinson's disease.
|
25369767 |
2015 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study suggests MANF exhibits potential as a neuroprotective agent for PD therapy.
|
29959908 |
2018 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Glial cell line-derived neurotrophic factor (GDNF), cerebral dopamine neurotrophic factor (CDNF), and mesencephalic astrocyte-derived neurotrophic factor (MANF) have shown neuroprotective and restorative effects on nigral dopaminergic neurons in various animal models of Parkinson's disease.
|
29349573 |
2018 |